The Blood Lactate-pyruvate Relation and Its Use in Experimektal Thiamine Deficiency in Pigeons
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Carbohydrate Metabolism in Thiamine Deficiency*
The relationship of vitamin Br to carbohydrate metabolism was one of the earliest functions of a vitamin to be observed. The problem has been more or less continuously investigated up to the present time and the majority of the evidence indicates that in vitamin B1 deficiency there is some interference with glycogen storage, hyperglycemia, and characteristic errors in carbohydrate metabolism. E...
متن کاملCarbohydrate Metabolism in Thiamine Deficiency*
The relationship of vitamin Br to carbohydrate metabolism was one of the earliest functions of a vitamin to be observed. The problem has been more or less continuously investigated up to the present time and the majority of the evidence indicates that in vitamin B1 deficiency there is some interference with glycogen storage, hyperglycemia, and characteristic errors in carbohydrate metabolism. E...
متن کاملExperimental Thiamine Deficiency TRENDS OF KETO ACID FORMATION AND DETECTION OF GLYOXYLIC ACID BY CHI-CHIN LIANG
Thiamine deficiency leads to a well-defined biochemical lesion of carbohydrate metabolism with increase in pyruvate and lactate in the blood (Peters, 1936). Since Lohmann & Schuster (1937) showed that thiamine in the ester form of pyrophosphate is the coenzyme for the decarboxylation of pyruvic acid, it has been found to participate in several important reactions of carbohydrate metabolism, in ...
متن کاملThiamine and Cocarboxylase Concentration
In patients with congestive heart failure, thiamine deficiency has been demonstrated by the test-dose method (1, 2), by measurement of the lactate-pyruvate ratio of the blood (3), and by determination of blood cocarboxylase (4). The oxidation of pyruvate to acetate requires thiamine in the form of cocarboxylase (thiamine pyrophosphate). Olson, Pearson, Miller, and Stare have shown that thiamine...
متن کاملLxxx. Blood Pyruvate in Vitamin B1 Deficiency
IN the course of recent work on the role of vitamin B, in the metabolism of brain, it was discovered [Peters and Sinclair, 1933] that lactate solutions in which avitaminous pigeon's brain cells had respired for 2 hours gave a positive nitroprusside reaction for pyruvic acid [Simon and Piaux, 1924]. This led to a quantitative investigation of the formation of pyruvic acid during the respiration ...
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تاریخ انتشار 2003